Michael Smith Selected Research

parsaclisib

3/2024	Correction: Combination of Itacitinib or Parsaclisib with Pembrolizumab in Patients with Advanced Solid Tumors: A Phase I Study.
12/2023	Combination of Itacitinib or Parsaclisib with Pembrolizumab in Patients with Advanced Solid Tumors: A Phase I Study.
1/2022	Exploring the safety, effect on the tumor microenvironment, and efficacy of itacitinib in combination with epacadostat or parsaclisib in advanced solid tumors: a phase I study.

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Michael Smith Research Topics

Disease

24	Neoplasms (Cancer) 03/2024 - 01/2002
8	Glaucoma 05/2023 - 04/2009
8	Prostatic Neoplasms (Prostate Cancer) 01/2023 - 12/2002
6	Infections 01/2022 - 12/2011
4	Neuromyelitis Optica (Devic's Disease) 06/2024 - 01/2021
4	COVID-19 06/2024 - 04/2022
4	Breast Neoplasms (Breast Cancer) 07/2023 - 04/2002
4	Pain (Aches) 01/2023 - 01/2018
3	Diarrhea 12/2023 - 01/2019
3	Fever (Fevers) 12/2023 - 06/2003
3	Nausea 12/2023 - 09/2017
3	Epilepsy (Aura) 01/2023 - 08/2013
3	Inflammation (Inflammations) 01/2021 - 11/2002
3	Hypersensitivity (Allergy) 01/2021 - 09/2002
3	Clostridium Infections 01/2021 - 01/2019
3	Hypertension (High Blood Pressure) 01/2020 - 01/2007
3	Wounds and Injuries (Trauma) 02/2014 - 02/2005
2	Respiratory Insufficiency (Respiratory Failure) 06/2024 - 09/2017
2	Pneumonia (Pneumonitis) 06/2024 - 01/2017
2	Fatigue 12/2023 - 01/2022
2	Sleep Initiation and Maintenance Disorders (Insomnia) 03/2023 - 05/2010
2	Thrombosis (Thrombus) 01/2023 - 04/2022
2	Tobacco Use Disorder (Nicotine Dependence) 11/2022 - 01/2022
2	Vomiting 01/2022 - 09/2017
2	Cardiac Arrhythmias (Arrythmia) 01/2021 - 01/2020
2	Shock 10/2020 - 10/2020
2	Renal Insufficiency (Renal Failure) 07/2020 - 07/2019
2	Chronic Pain 01/2020 - 01/2018
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/2019 - 06/2009
2	Seizures (Absence Seizure) 01/2019 - 09/2012
2	Hyponatremia 01/2019 - 08/2016
2	Cardiovascular Diseases (Cardiovascular Disease) 02/2018 - 11/2008
2	Constipation 09/2017 - 01/2007
2	Melanoma (Melanoma, Malignant) 05/2017 - 01/2002
2	Acute Kidney Injury (Acute Renal Failure) 01/2017 - 06/2009
2	Dental Caries (Decay, Dental) 09/2015 - 06/2011
2	Uveitis 07/2013 - 04/2007
2	Schizophrenia (Dementia Praecox) 05/2010 - 01/2010
2	Multiple Myeloma 01/2010 - 06/2009
1	Urinary Tract Infections (Urinary Tract Infection) 06/2024
1	Nasopharyngitis 06/2024
1	Viral Pneumonia 06/2024
1	Arthralgia (Joint Pain) 06/2024
1	Hemorrhage 04/2024
1	Hemorrhagic Shock 04/2024
1	Exanthema (Rash) 12/2023
1	Anemia 12/2023
1	Disease Progression 12/2023
1	Pruritus (Itching) 12/2023

Drug/Important Bio-Agent (IBA)

4	inebilizumabIBA 06/2024 - 01/2021
4	VaccinesIBA 05/2023 - 06/2003
3	parsaclisibIBA 03/2024 - 01/2022
3	itacitinibIBA 03/2024 - 01/2022
3	pembrolizumabIBA 03/2024 - 01/2023
3	COVID-19 VaccinesIBA 05/2023 - 01/2022
3	AntigensIBA 05/2023 - 04/2002
3	LigandsIBA 01/2023 - 11/2002
3	Opioid Analgesics (Opioids)IBA 01/2020 - 09/2017
3	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 09/2002
3	Diphosphonates (Bisphosphonates)IBA 08/2016 - 03/2007
3	Zoledronic Acid (Zometa)FDA Link 01/2010 - 03/2007
2	Immunoglobulin G (IgG)IBA 06/2024 - 01/2021
2	Messenger RNA (mRNA)IBA 05/2023 - 04/2022
2	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2014
2	epacadostatIBA 01/2023 - 01/2022
2	Menthol FDA Link 11/2022 - 01/2022
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 01/2019
2	CytokinesIBA 01/2021 - 08/2015
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2002
2	ElectrolytesIBA 08/2016 - 08/2007
2	SteroidsIBA 07/2013 - 09/2011
2	Hormones (Hormone)IBA 02/2012 - 03/2007
2	GadoliniumIBA 02/2012 - 01/2010
2	Dexamethasone (Maxidex)FDA LinkGeneric 09/2011 - 05/2002
2	Risperidone (Risperdal Consta)FDA LinkGeneric 05/2010 - 01/2010
2	Ibandronic Acid (Boniva)FDA Link 01/2010 - 06/2009
2	Polysaccharides (Glycans)IBA 11/2002 - 04/2002
2	Antiviral Agents (Antivirals)IBA 10/2002 - 09/2002
2	Imiquimod (Aldara)FDA LinkGeneric 10/2002 - 09/2002
1	Oxygen (Dioxygen)IBA 04/2024
1	Recombinant ProteinsIBA 05/2023
1	2019-nCoV Vaccine mRNA-1273IBA 05/2023
1	BNT162 VaccineIBA 05/2023
1	N-(2-cyanoethylene)urea (BA 1)IBA 05/2023
1	Combined VaccinesIBA 05/2023
1	EndotoxinsIBA 03/2023

Therapy/Procedure

13	Therapeutics 06/2024 - 12/2002
4	Radiotherapy 01/2015 - 01/2005
3	Phacoemulsification 05/2023 - 04/2007
3	Immunotherapy 01/2023 - 04/2002
3	Lasers (Laser) 01/2021 - 03/2010
3	Resuscitation 10/2020 - 01/2017
3	Conservative Treatment 07/2020 - 02/2014
3	Drug Therapy (Chemotherapy) 01/2019 - 02/2012
2	Lung Transplantation 02/2018 - 12/2014
2	Length of Stay 02/2018 - 01/2015
2	Intraocular Lenses (Intraocular Lens) 03/2010 - 04/2007
2	Vitrectomy 03/2010 - 04/2007
1	Treatment Delay 07/2023
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 02/2023